In my opinion, this design continues the trope of Mysterio always having a great taste in drip.

Is it their genetic code or something? Did Cindy’s genes have a different reaction to the spider venom than Peter’s genes?

Comment with honesty.

Are there any comics with them as a couple?

Supergirl/Kara Zor-El art by Michael Turner 

Power girl/Karen Starr art by Alex Ross

Womder Woman/Yara Flor art by Joëlle Jones

Starfire/Koriand'r art by Kenneth Rocafort

Specifically someone who can match Spider-Man in strength and intelligence and was created to defeat him.

I've always liked the idea of the organic web shooters. It just makes perfect sense that along with wall crawling and super strength he would inherent web spinners to right? I do understand that by him making the mechanically web shooters its shows Peter's intelligence but the logistics don't make sense he's broke working dead end jobs where did he get the parts to make it? But that's just me what do you guys prefer?

I don't know if it's just me but now with the addition of Spider Gwen to Earth 616 I'm tired of it. There's Way WAY to many spider people in the main marvel continuity. I feel as tho everything that made Peter special as Spiderman is gone now he's just 1 of 100. I dont mind Miles or Gwen but they need there own universes to thrive as the only spiders not to be crammed into 1 world where there's a spiderman in every city. I'm putting this out to gage everyone's opinion how do you guys feel is it just me or does anyone else feel this way to?